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Dysbiosis of the intestinal flora also affects the process of AD [149], and transplantation of a healthy microbiota improves the cognitive deficits and reduces A and Tau deposition in AD model mice [150]

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Regarding safety, the incidence of grade 3 peripheral sensory neuropathy for both regimens was significantly lower than historically reported rates for ixabepilone monotherapy or its combination with capecitabine

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